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Symbol Name ID |
Gba1
glucosylceramidase beta 1 MGI:95665 |
| Darker colors indicate more annotations |
| Human Phenotypes | Polyclonal elevation of IgM |
Increased circulating antibody level |
Leukopenia |
Bacterial endocarditis |
Abnormality of the spleen |
Splenic infarction |
Splenic rupture |
Splenomegaly |
Hepatosplenomegaly |
Hypersplenism |
Hepatitis |
Osteomyelitis |
Recurrent aspiration pneumonia |
Recurrent respiratory infections |
Bronchiolitis |
| Disease(s) Associated with GBA1 | |||||||||||||||
| Gaucher's disease | |||||||||||||||
| Gaucher's disease perinatal lethal | |||||||||||||||
| Gaucher's disease type I | |||||||||||||||
| Gaucher's disease type II | |||||||||||||||
| Gaucher's disease type III | |||||||||||||||
| Gaucher's disease type IIIC |
| Mouse Phenotypes | abnormal Kupffer cell morphology |
abnormal thymus morphology |
enlarged spleen |
increased spleen weight |
spleen hyperplasia |
abnormal T cell differentiation |
decreased double-positive T cell number |
decreased leukocyte cell number |
abnormal macrophage morphology |
abnormal microglial cell morphology |
abnormal spleen morphology |
intermingled spleen red and white pulp |
increased IgG level |
abnormal circulating cytokine level |
abnormal circulating chemokine level |
increased circulating interferon-gamma level |
decreased circulating interleukin-1 alpha level |
decreased circulating interleukin-1 beta level |
increased circulating interleukin-10 level |
increased circulating interleukin-13 level |
increased circulating interleukin-2 level |
increased circulating interleukin-3 level |
decreased circulating interleukin-6 level |
increased circulating interleukin-9 level |
decreased circulating tumor necrosis factor level |
abnormal immune system organ morphology |
abnormal lymph node morphology |
abnormal spleen physiology |
lymph node inflammation |
abnormal inflammatory response |
liver inflammation |
lung inflammation |
skin inflammation |
abnormal response to transplant |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||
| Gba1tm1Nsb/Gba1tm1Nsb | |||||||||||||||||||||||||||||||||||
| Gba1tm1Rlp/Gba1tm1Rlp | |||||||||||||||||||||||||||||||||||
| Gba1tm2Ggb/Gba1tm2Ggb | |||||||||||||||||||||||||||||||||||
| Gba1tm3Ggb/Gba1tm3Ggb | |||||||||||||||||||||||||||||||||||
| Gba1tm4Ggb/Gba1tm4Ggb | |||||||||||||||||||||||||||||||||||
| Gba1tm2Ggb/Gba1tm1Nsb | |||||||||||||||||||||||||||||||||||
| Gba1tm3Ggb/Gba1tm1Nsb | |||||||||||||||||||||||||||||||||||
| Gba1tm4Ggb/Gba1tm1Nsb | |||||||||||||||||||||||||||||||||||
| Gba1tm1.1Pmis/Gba1tm1.1Pmis Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Gba1tm1Karl/Gba1tm1Karl Tg(Nes-cre)1Kln/? (conditional) |
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| Gba1tm2Karl/Gba1tm2Karl Tg(KRT14-cre)8Brn/? (conditional) |
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| Gba1tm1.1Pmis/Gba1tm1.2Pmis Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Gba1tm1Clk/Gba1tm1.1Clk Tg(Tek-cre)12Flv/0 (conditional) |
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| Gba1tm1Karl/Gba1tm1.1Karl Tg(Mx1-cre)1Cgn/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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